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Before taking Brilinta

You should not use ticagrelor if you are allergic to it, or if you have:

• severe liver disease;

• any active bleeding;

• stomach ulcer or bleeding; or

• a history of bleeding in the brain (such as from a head injury).

Do not use Brilinta within 5 days before heart bypass surgery (coronary artery bypass graft, or CABG).

To make sure ticagrelor is safe for you, tell your doctor if you have:

• liver disease;

• a serious heart condition such as "sick sinus syndrome" or "AV block" (unless you have a pacemaker);

• asthma, COPD (chronic obstructive pulmonary disorder) or other breathing problem;

• a history of stomach ulcer or colon polyps;

• a history of stroke; or

• a history of bleeding or blood clotting disorder.

Ticagrelor may cause you to bleed more easily, especially if you have:

• a recent surgery or bleeding injury;

• a disease affecting the blood vessels in your brain;

• a history of stroke;

• a history of bleeding problems;

• a history of stomach or intestinal bleeding; or

• if you are 65 or older.

It is not known whether Brilinta will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.

It is not known whether ticagrelor passes into breast milk or if it could harm a nursing baby. You should not breast-feed while using Brilinta.

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